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Biomechanical Engineering Courses

Undergraduate

ME 10N Form and Function of Animal Skeletons

(Same as BioE 10N) Preference to freshmen. The biomechanics and mechanobiology of the musculoskeletal system in human beings and other vertebrates on the level of the whole organism, organ systems, tissues and cell biology. Field trips to labs. Preference to freshmen; sophomores admitted if space available. Application required. 3 units (Carter, D)

BIOE 70Q Medical Device Innovation

Stanford Introductory Seminar. Preference to sophomores. Commonly used medical devices in different medical specialties. Guest lecturers include Stanford Medical School physicians, entrepreneurs and venture capitalists. How to identify clinical needs and design device solutions to address these needs. Fundamentals of starting a company. Field trips to local medical device companies; workshops. No previous engineering training required. 3 units, Spr (Mandato, J; Milroy, J; Doshi, R)

Advanced Undergraduate and Beginning Graduate Courses

BIOE 220 Imaging Anatomy

(Same as RAD 220.) The physics of medical imaging and human anatomy through medical images. Emphasis is on normal anatomy, contrast mechanisms and the relative strengths of each imaging modality. Labs reinforce imaging techniques and anatomy. Prerequisites: basic biology, physics.
3 units, Win (Gold, G; Pauly, K)

ME 280 Skeletal Development and Evolution

The mechanobiology of skeletal growth, adaptation, regeneration, and aging is considered from developmental and evolutionary perspectives. Emphasis is on the interactions between mechanical and chemical factors in the regulation of connective tissue biology. Prerequisites: 80, or Human Biology core, or Biological Sciences core. 3 units (Carter, D)

ME 281 Biomechanics of Movement

(Same as BIOE 281.) Experimental techniques to study human and animal movement including motion capture systems, EMG, force plates, medical imaging and animation. The mechanical properties of muscle and tendon, and quantitative analysis of musculoskeletal geometry. Projects and demonstrations emphasize applications of mechanics in sports, orthopedics and rehabilitation. 3 units (Delp, S)

ME 284A Cardiovascular Biomechanics

(Same as BIOE 284A.) Bioengineering principles applied to the cardiovascular system. Anatomy of human cardiovascular system, comparative anatomy and allometric scaling principles. Cardiovascular molecular and cell biology. Overview of continuum mechanics. Form and function of blood, blood vessels and the heart from an engineering perspective. Normal, diseased and engineered replacement tissues. 3 units (Taylor, C)

ME 284B Cardiovascular Biomechanics

(Same as BIOE 284B.) Continuation of ME 284A. Integrative cardiovascular physiology, blood fluid mechanics and transport in the microcirculation. Sensing, feedback and control of the circulation. Overview of congenital and adult cardiovascular disease, diagnostic methods and treatment strategies. Engineering principles to evaluate the performance of cardiovascular devices and the efficacy of treatment strategies. 3 units (Taylor, C)

ME 287 Soft Tissue Mechanics

Structure/function relationships and mechanical properties of soft tissues, including nonlinear elasticity, viscoelasticity and poroelasticity. 3 units (Levenston, M)

ME 294 Medical Device Design

In collaboration with the School of Medicine. Introduction to medical device design for undergraduate and graduate engineering students. Design and prototyping. Labs; medical device environments including hands-on device testing; and field trips to operating rooms and local device companies. Limited enrollment. Prerequisite: 203. 3 units (Milroy, J; Doshi, R)

Graduate

BIOE 335 Molecular Motors I: F1 ATPase

Physical mechanisms of mechanochemical coupling in biological molecular motors, using F1 ATPase as the principal model system. Applications of biochemistry, structure determination, single molecule tracking and manipulation, protein engineering and computational techniques to the study of molecular motors. 3 units, Spr (Bryant, Z)

ME 337 Mechanics of Growth

Introdution to continuum theory and numerical solutions or biomechanical problems. Kinematics of finite growth. Balance equations in open system thermodynamics. Constitutive equations for biological tissues. Enhanced finite element models in biomechanics. Analytical solutions for simple model problems. Numerical solutions for more advanced problems such as: bone remodeling, wound healing, muscle regeneration, tumor growth, atherosclerosis, in-stent restenosis and tissue engineering. 3 units (Kuhl, E)

ME 339 Mechanics of the Cell

Kinematical description of basic structural elements used to model parts of the cell: rods, ropes, membranes and shells. Formulation of constitutive equations: nonlinear elasticity and entropic contributions. Elasticity of polymeric networks. Applications to model basic filaments of the cytoskeleton: actin, microtubules, intermediate filaments and complete networks. Applications to biological membranes. 3 units (Kuhl, E)

ME 341 Biomechanics of Hearing, Speech and Balance

Theory and practice of building mathematical models to understand physical phenomena; integration of imaging, physiology and biomechanics. Journal club-style discussions of research literature, examples from hearing science, speech production and the vestibular system. Dualisms in modeling include: general principles versus detailed models, analytic versus computational models, forward versus inverse approaches, and the interplay between theory and experiments. 3 units (Puria, S)

BIOE 370 Microfluidic Device Laboratory

Fabrication of microfluidic devices for biological applications. Photolithography, soft lithography and micromechanical valves and pumps. Emphasis is on device design, fabrication and testing. 2 units, Win (Quake, S)

ME 374A Biodesign Innovation: Needs Finding and Concept Creation

(Same as BIOE 374A, OIT 384, MED 272A.) Two-quarter sequence. Strategies for interpreting clinical needs, researching literature and searching patents. Clinical and scientific literature review, techniques of intellectual property analysis and feasibility, basic prototyping, and market assessment. Student entrepreneurial teams create, analyze and screen medical technology ideas, and select projects for development. 3-4 units (Yock, P; Zenios, S; Brinton; Milroy, C)

ME 374B Biodesign Innovation: Concept Development and Implementation

(Same as BIOE 374B, OIT 385, MED 272B.) Two-quarter sequence. Concept development and implementation. Early factors for success; how to prototype inventions and refine intellectual property. Lectures, guest medical pioneers and entrepreneurs about strategic planning, ethical considerations, new venture management, and financing and licensing strategies. Cash requirements; regulatory (FDA), reimbursement, clinical and legal strategies, and business or research plans. 3-4 units (Yock, P; Zenios, S; Brinton; Milroy, C)

ME 382A Medical Device Design

Real-world problems and challenges of biomedical device design and evaluation. Students engage in industry-sponsored projects resulting in new designs, physical prototypes, design analyses, computational models and experimental tests, gaining experience in: the formation of design teams; interdisciplinary communication skills; regulatory issues; biological, anatomical and physiological considerations; testing standards for medical devices; and intellectual property. 4 units (Andriacchi, T)

ME 382B Medical Device Design

Continuation of industry-sponsored projects from 382A. With the assistance of faculty and expert consultants, students finalize product designs or complete detailed design evaluations of new medical products. Bioethics issues and strtegies for funding new medical ventures. 4 units (Andriacchi, T)

ME 385 Tissue Engineering Lab

Hands-on experience in the fabrication of living engineered tissues. Techniques include sterile technique, culture of mammalian cells, creation of cell-seeded scaffolds, and the effects of mechanical loading on the metabolism of living engineered tissues. Theory, background and practical demonstration for each technique. Lab. 1-2 units (TBA)

BIOE 390 Introduction to Bioengineering Research

(Same as MED 289.) Bioengineering is an interdisciplinary field that leverages the disciplines of biology, medicine and engineering to understand living systems, and engineer biological systems and improve engineering designs and human and environmental health. Topics include: imaging; molecular, cell and tissue engineering; biomechanics; biomedical computation; biochemical engineering; biosensors; and medical devices. Limited enrollment. 1-2 units, Aut (Taylor, C), Win (Taylor, C)

Advanced Graduate

ME 484 Computational Methods in Cardiovascular Bioengineering

(Same as BIOE 484.) Lumped parameter, one-dimensional nonlinear and linear wave propagation, and three-dimensional modeling techniques applied to simulate blood flow in the cardiovascular system and evaluate the performance of cardiovascular devices. Construction of anatomic models and extraction of physiologic quantities from medical imaging data. Problems in blood flow within the context of disease research, device design and surgical planning. 3 units (Taylor, C)

ME 485 Modeling and Simulation of Human Movement

(Same as BIOE 485.) Direct experience with the computational tools used to create simulations of human movement. Lecture/labs on animation of movement; kinematic models of joints; forward dynamic simulation; computational models of muscles, tendons and ligaments; creation of models from medical images; control of dynamic simulations; collision detection and contact models. Prerequisite: 281, 331A,B, or equivalent. 3 units (Delp, S)

Seminars

BioE 393 Biomechanical Engineering Research Seminar

BME research conducted at Stanford for incoming students. Graduate students and postdoctoral fellows present research emphasizing motivation of research questions, project design, methods and prelminary results. 1 unit (TBA)

ME 398 Biomechanical Research Symposium

Guest speakers present contemporary research on experimental and theoretical aspects of biomechanical engineering and bioengineering. May be repeated for credit. 1 unit (Levenston, M)